|Other Names||Protein phosphatase 1 regulatory subunit 3C, Protein phosphatase 1 regulatory subunit 5, PP1 subunit R5, Protein targeting to glycogen, PTG, PPP1R3C (HGNC:9293)|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.|
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Provided below are standard protocols that you may find useful for product applications.
Protein phosphatase-1 (PP1; see MIM 176875) participatesin the regulation of a wide variety of cellular functions byreversible protein phosphorylation. The ability of PP1 to regulatediverse functions resides in its capacity to interact with avariety of regulatory subunits that may target PP1 to specificsubcellular locations, modulate its substrate specificity, andallow its activity to be responsive to extracellular signals.Several targeting subunits of PP1 have been identified, includingPPP1R5, the glycogen-binding subunits PPP1R3 (MIM 600917) andPPP1R4, and the nuclear inhibitor of PP1 (PPP1R8; MIM602636).
Vernia, S., et al. J. Biol. Chem. 284(13):8247-8255(2009)Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)Fernandez-Sanchez, M.E., et al. Hum. Mol. Genet. 12(23):3161-3171(2003)
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