|Other Names||Kin of IRRE-like protein 1, Kin of irregular chiasm-like protein 1, Nephrin-like protein 1, KIRREL, KIRREL1, NEPH1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=Predominantly located at podocyte slit diaphragm|
|Tissue Location||Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli|
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Provided below are standard protocols that you may find useful for product applications.
NEPH1 is a member of the nephrin-like protein family,which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). Thecytoplasmic domains of these proteins interact with the C terminusof podocin (NPHS2; MIM 604766), and the genes are expressed inkidney podocytes, cells involved in ensuring size- andcharge-selective ultrafiltration (Sellin et al., 2003 [PubMed12424224]).
Huber, T.B., et al. J. Biol. Chem. 278(15):13417-13421(2003)Gerke, P., et al. J. Am. Soc. Nephrol. 14(4):918-926(2003)Sellin, L., et al. FASEB J. 17(1):115-117(2003)Donoviel, D.B., et al. Mol. Cell. Biol. 21(14):4829-4836(2001)
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