|Other Names||Kin of IRRE-like protein 1, Kin of irregular chiasm-like protein 1, Nephrin-like protein 1, KIRREL, KIRREL1, NEPH1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=Predominantly located at podocyte slit diaphragm|
|Tissue Location||Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
NEPH1 is a member of the nephrin-like protein family,which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). Thecytoplasmic domains of these proteins interact with the C terminusof podocin (NPHS2; MIM 604766), and the genes are expressed inkidney podocytes, cells involved in ensuring size- andcharge-selective ultrafiltration (Sellin et al., 2003 [PubMed12424224]).
Huber, T.B., et al. J. Biol. Chem. 278(15):13417-13421(2003)Gerke, P., et al. J. Am. Soc. Nephrol. 14(4):918-926(2003)Sellin, L., et al. FASEB J. 17(1):115-117(2003)Donoviel, D.B., et al. Mol. Cell. Biol. 21(14):4829-4836(2001)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.