|Other Names||Killer cell immunoglobulin-like receptor 2DL2, CD158 antigen-like family member B1, MHC class I NK cell receptor, Natural killer-associated transcript 6, NKAT-6, p58 natural killer cell receptor clone CL-43, p58 NK receptor CL-43, CD158b1, KIR2DL2, CD158B1, NKAT6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Killer cell immunoglobulin-like receptors (KIRs) aretransmembrane glycoproteins expressed by natural killer cells andsubsets of T cells. The KIR genes are polymorphic and highlyhomologous and they are found in a cluster on chromosome 19q13.4within the 1 Mb leukocyte receptor complex (LRC). The gene contentof the KIR gene cluster varies among haplotypes, although several'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,KIR3DL4, KIR3DL2). The KIR proteins are classified by the number ofextracellular immunoglobulin domains (2D or 3D) and by whether theyhave a long (L) or short (S) cytoplasmic domain. KIR proteins withthe long cytoplasmic domain transduce inhibitory signals uponligand binding via an immune tyrosine-based inhibitory motif(ITIM), while KIR proteins with the short cytoplasmic domain lackthe ITIM motif and instead associate with the TYRO protein tyrosinekinase binding protein to transduce activating signals. The ligandsfor several KIR proteins are subsets of HLA class I molecules;thus, KIR proteins are thought to play an important role inregulation of the immune response.
Snyder, G.A., et al. Proc. Natl. Acad. Sci. U.S.A. 96(7):3864-3869(1999)Stuart, G.R., et al. Immunopharmacology 38 (1-2), 73-80 (1997) :Dohring, C., et al. Immunogenetics 44(3):227-230(1996)Wagtmann, N., et al. Immunity 2(5):439-449(1995)
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