AFTPH Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q6ULP2 |
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Other Accession | NP_001002243.1 |
Clone Names | 91102284 |
Gene ID | 54812 |
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Other Names | Aftiphilin, AFTPH, AFTH |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | AFTPH |
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Synonyms | AFTH |
Function | Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). |
Cellular Location | Cytoplasm. Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Co-localizes with AP1G1/AP- 1 in the cytoplasm (PubMed:14665628, PubMed:15758025). Recruited to the perinuclear region by AP1G1/AP-1 (PubMed:15758025) |
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Provided below are standard protocols that you may find useful for product applications.
Background
AFTPH may play a role in membrane trafficking.
References
Lui-Roberts, W.W., et al. Mol. Biol. Cell 19(12):5072-5081(2008)Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)Hirst, J., et al. Mol. Biol. Cell 16(5):2554-2565(2005)Burman, J.L., et al. FEBS Lett. 579(10):2177-2184(2005)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)Mattera, R., et al. J. Biol. Chem. 279(9):8018-8028(2004)
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