|Other Names||GPI mannosyltransferase 4, 241-, GPI mannosyltransferase IV, GPI-MT-IV, Phosphatidylinositol-glycan biosynthesis class Z protein, PIG-Z, SMP3 homolog, hSMP3, PIGZ, SMP3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed at low level, with highest level in brain and colon.|
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Provided below are standard protocols that you may find useful for product applications.
The glycosylphosphatidylinositol (GPI) anchor is aglycolipid found on many blood cells that serves to anchor proteinsto the cell surface. This gene encodes a protein that is localizedto the endoplasmic reticulum, and is involved in GPI anchorbiosynthesis. As shown for the yeast homolog, which is a member ofa family of dolichol-phosphate-mannose (Dol-P-Man)-dependentmannosyltransferases, this protein can also add a side-branchingfourth mannose to GPI precursors during the assembly of GPIanchors.
Taron, B.W., et al. J. Biol. Chem. 279(34):36083-36092(2004)Eisenhaber, B., et al. Bioessays 25(4):367-385(2003)Oriol, R., et al. Mol. Biol. Evol. 19(9):1451-1463(2002)Grimme, S.J., et al. J. Biol. Chem. 276(29):27731-27739(2001)
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