|Other Names||Potassium voltage-gated channel subfamily V member 1, Neuronal potassium channel alpha subunit HNKA, Voltage-gated potassium channel subunit Kv81, KCNV1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Note=Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2|
|Tissue Location||Detected in brain.|
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Provided below are standard protocols that you may find useful for product applications.
Voltage-gated potassium (Kv) channels represent the mostcomplex class of voltage-gated ion channels from both functionaland structural standpoints. Their diverse functions includeregulating neurotransmitter release, heart rate, insulin secretion,neuronal excitability, epithelial electrolyte transport, smoothmuscle contraction, and cell volume. This gene encodes a member ofthe potassium voltage-gated channel subfamily V. This protein isessentially present in the brain, and its role might be to inhibitthe function of a particular class of outward rectifier potassiumchannel types.
Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)Ebihara, M., et al. Gene 325, 89-96 (2004) :Sano, A., et al. Epilepsia 43 SUPPL 9, 26-31 (2002) :Salinas, M., et al. J. Biol. Chem. 272(13):8774-8780(1997)Hugnot, J.P., et al. EMBO J. 15(13):3322-3331(1996)
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