MNS1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8NEH6 |
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Other Accession | NP_060835.1 |
Clone Names | 91201237 |
Gene ID | 55329 |
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Other Names | Meiosis-specific nuclear structural protein 1, MNS1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MNS1 (HGNC:29636) |
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Function | Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. Required for sperm flagella assembly (By similarity). May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules (PubMed:30148830). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q61884}. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Note=Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme. {ECO:0000250|UniProtKB:Q2KIQ2} |
Tissue Location | Expressed in nasal respiratory epithelium and in the sperm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
MNS1 is a protein highly similar to the mousemeiosis-specific nuclear structural 1 protein. The mouse proteinwas shown to be expressed at the pachytene stage duringspermatogenesis and may function as a nuclear skeletal protein toregulate nuclear morphology during meiosis.
References
Shakib, K., et al. Proteomics 5(11):2819-2838(2005)Hotta, Y., et al. Adv. Biophys. 31, 101-115 (1995) :Furukawa, K., et al. Chromosome Res. 2(2):99-113(1994)
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