hCG_2039146 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | A6NL88 |
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Other Accession | NP_001138648.1 |
Clone Names | 91230099 |
Gene ID | 729956 |
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Other Names | Protein shisa-7, Protein shisa-6-like, SHISA7 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SHISA7 (HGNC:35409) |
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Function | Transmembrane protein that regulates gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory transmission in the brain. Enhances the action of benzodiazepine, a primary GABA(A)Rs target drug, in the brain. May affect channel kinetics of AMPA-type glutamate receptors (AMPAR), the brain's main excitatory neurotransmitter, necessary for synaptic hippocampal plasticity, and memory recall. May regulate the induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 excitatory synapses. |
Cellular Location | Postsynaptic density membrane {ECO:0000250|UniProtKB:Q8C3Q5}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8C3Q5}. Note=Localizes at GABAergic inhibitory synapses and colocalizes with gephyrin in hippocampal neurons {ECO:0000250|UniProtKB:Q8C3Q5} |
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Provided below are standard protocols that you may find useful for product applications.
References
Grimwood, J., et al. Nature 428(6982):529-535(2004)Venter, J.C., et al. Science 291(5507):1304-1351(2001)
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