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T4S20 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q53R12
Other Accession NP_079071.2
Clone Names 91208061
Peptide ID 91208061
Additional Information
Gene ID 79853
Other Names Transmembrane 4 L6 family member 20, TM4SF20
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TM4SF20
Function Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293). In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1 (PubMed:27499293). Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein (PubMed:27499293).
Cellular Location Membrane; Multi-pass membrane protein Endoplasmic reticulum membrane; Multi-pass membrane protein Note=Ceramide alters the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20.
Tissue Location Expressed in the brain, with high levels in the parietal lobe, hippocampus, pons, white matter and cerebellum
Research Areas
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$ 80.00
Cat# BP5920b
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