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OTUD4 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q01804
Other Accession NP_001096123.1, NP_059963.1
Clone Names 91102261
Additional Information
Gene ID 54726
Other Names OTU domain-containing protein 4, HIV-1-induced protein HIN-1, OTUD4, HIN1, KIAA1046
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name OTUD4 (HGNC:24949)
Function Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase- substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111).
Cellular Location Cytoplasm. Nucleus. Note=Primarily cytoplasmic
Research Areas
Citations (0)
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$ 277.78
Cat# BP5997a
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