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Collagen I (COL1A1) Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P02452 |
|---|---|
| Clone Names | 2082311 |
| Gene ID | 1277 |
|---|---|
| Other Names | Collagen alpha-1(I) chain, Alpha-1 type I collagen, COL1A1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6107a was selected from the C-term region of human COL1A1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | COL1A1 |
|---|---|
| Function | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| Cellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793} |
| Tissue Location | Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite |
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Provided below are standard protocols that you may find useful for product applications.
Background
COL1A1 is the major component of type I collagen, and the sole component of the collagen located in cartilage. COL1A1 mutations are associated with osteogenesis imperfecta type I, II, III, and IV, Ehlers-Danlos syndrome type I and II, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a skin tumor called dermatofibrosarcoma protuberans. Two COL1A1 transcripts arise from variant polyadenylation signals for this gene.
References
Sandberg, A.A., et al., Cancer Genet. Cytogenet. 142(1):56-59 (2003).Nuytinck, L., et al., Am. J. Hum. Genet. 66(4):1398-1402 (2000).Sarafova, A.P., et al., Hum. Mutat. 11(5):395-403 (1998).Mottes, M., et al., Hum. Mutat. 12(1):71-72 (1998).Lund, A.M., et al., Hum. Mutat. 9(5):431-436 (1997).
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