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P-Glycoprotein (ABCB1) Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P08183
Clone Names 2092001
Additional Information
Gene ID 5243
Other Names Multidrug resistance protein 1, ATP-binding cassette sub-family B member 1, P-glycoprotein 1, CD243, ABCB1, MDR1, PGY1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6111a was selected from the Center region of human ABCB1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABCB1
Synonyms MDR1, PGY1
Function Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Cellular Location Cell membrane; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}
Tissue Location Expressed in liver, kidney, small intestine and brain
Research Areas
Citations (0)

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The membrane-associated ABCB1 protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. ABCB1 is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.


Saito, S., et al., J. Hum. Genet. 47(1):38-50 (2002).Kerb, R., et al., Pharmacogenomics 2(1):51-64 (2001).Cascorbi, I., et al., Clin. Pharmacol. Ther. 69(3):169-174 (2001).Hoffmeyer, S., et al., Proc. Natl. Acad. Sci. U.S.A. 97(7):3473-3478 (2000).Mickley, L.A., et al., Blood 91(5):1749-1756 (1998).

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$ 80.00
Cat# BP6111a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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