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ABCB4 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P21439
Clone Names 2092002
Peptide ID 2092002
Additional Information
Gene ID 5244
Other Names Multidrug resistance protein 3, ATP-binding cassette sub-family B member 4, P-glycoprotein 3, ABCB4, MDR3, PGY3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6112a was selected from the Center region of human ABCB4 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABCB4
Synonyms MDR3, PGY3
Function Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.
Cellular Location Cell membrane; Multi-pass membrane protein.
Research Areas
Citations (0)

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The membrane-associated protein encoded ABCB4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.


Eloranta, M.L., et al., Eur J Obstet Gynecol Reprod Biol 105(2):132-135 (2002).Eloranta, M.L., et al., Eur J Obstet Gynecol Reprod Biol 104(2):109-112 (2002).Jacquemin, E., Semin. Liver Dis. 21(4):551-562 (2001).Smit, J.J., et al., Biochim. Biophys. Acta 1261(1):44-56 (1995).Ruetz, S., et al., Cell 77(7):1071-1081 (1994).

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$ 80.00
Cat# BP6112a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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