|Other Names||Kalirin, Huntingtin-associated protein-interacting protein, Protein Duo, Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain, KALRN, DUET, DUO, HAPIP, TRAD|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6120a was selected from the C-term region of human HAPIP . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DUET, DUO, HAPIP, TRAD|
|Function||Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton Note=Associated with the cytoskeleton|
|Tissue Location||Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Huntington's disease is an inherited neurodegenerative disease which occurs when the widely expressed protein huntingtin contains an expanded glutamine repeat. HAPIP binds to HAP1, which is a huntington binding protein that may function in vesicle trafficking.
Colomer, V., et al., Hum. Mol. Genet. 6(9):1519-1525 (1997).
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