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BACE2 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9Y5Z0
Clone Names 2091801
Peptide ID 2091801
Additional Information
Gene ID 25825
Other Names Beta-secretase 2, Aspartic-like protease 56 kDa, Aspartyl protease 1, ASP1, Asp 1, Beta-site amyloid precursor protein cleaving enzyme 2, Beta-site APP cleaving enzyme 2, Down region aspartic protease, DRAP, Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase, BACE2, AEPLC, ALP56, ASP21
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6121a was selected from the Center region of human BACE2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BACE2
Synonyms AEPLC, ALP56, ASP21
Function Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
Cellular Location Membrane; Single-pass type I membrane protein. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface
Tissue Location Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.
Research Areas
Citations (0)

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Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by BACE2. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease.


Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003).Basi, G., et al., J. Biol. Chem. 278(34):31512-31520 (2003).Barbiero, L., et al., Exp. Neurol. 182(2):335-345 (2003).Shi, X.P., et al., J. Biol. Chem. 278(23):21286-21294 (2003).Kondoh, K., et al., Breast Cancer Res. Treat. 78(1):37-44 (2003).

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$ 80.00
Cat# BP6121a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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