|Other Names||Homeobox protein CDX-2, CDX-3, Caudal-type homeobox protein 2, CDX2, CDX3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6131a was selected from the N-term region of human CDX2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.|
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The caudal type homeo box transcription factors 1 (CDX1) and 2 (CDX2) are candidates for directing intestinal development, differentiation, and maintenance of the intestinal phenotype. CDX1 and CDX2 expression is widely present in the human intestinal and colonic mucosae, but not in the gastric mucosa, suggesting a possible role in the terminal differentiation of the intestine. Increased CDX2 expression is associated with chronic atrophic gastritis. Detectable expression of CDX2 precedes expression of CDX1 during the progression of intestinal metaplasia, thus expression of CDX2 may trigger the initiation and development of intestinal metaplasia. Markedly reduced or absent CDX2 expression was noted by immunohistochemistry in 13 of 15 (87%) large cell minimally differentiated carcinomas (LCMDCs), whereas only 1 of the 25 (4%) differentiated adenocarcinomas (DACs) showed reduced CDX2 expression. Thus, a significant decrease in human CDX1 and/or CDX2 expression may be associated with colorectal tumorigenesis.
Phillips, R.W., et al., Am. J. Surg. Pathol. 27(11):1442-1447 (2003).Bai, Y.Q., et al., Oncogene 22(39):7942-7949 (2003).Yamamoto, H., et al., Biochem. Biophys. Res. Commun. 300(4):813-818 (2003).Eda, A., et al., J. Gastroenterol. 37(2):94-100 (2002).Moucadel, V., et al., Biochem. Biophys. Res. Commun. 297(3):607-615 (2002).
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