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EDG2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q92633
Other Accession NP_001392
Clone Names 2080601
Peptide ID 2080601
Additional Information
Gene ID 1902
Other Names Lysophosphatidic acid receptor 1, LPA receptor 1, LPA-1, Lysophosphatidic acid receptor Edg-2, LPAR1, EDG2, LPA1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6138a was selected from the N-term region of human EDG2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LPAR1
Synonyms EDG2, LPA1
Function Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation.
Cellular Location Cell surface. Cell membrane; Multi-pass membrane protein. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles
Tissue Location Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes
Research Areas
Citations (0)

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The EDG2 integral membrane protein is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion.


Matsuda, A., et al., Oncogene 22(21):3307-3318 (2003).Van Leeuwen, F.N., et al., J. Biol. Chem. 278(1):400-406 (2003).Shida, D., et al., Cancer Res. 63(7):1706-1711 (2003).Cervera, P., et al., Glia 38(2):126-136 (2002).An, S., et al., Mol. Pharmacol. 54(5):881-888 (1998).

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$ 80.00
Cat# BP6138a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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