|Other Names||Sphingosine 1-phosphate receptor 3, S1P receptor 3, S1P3, Endothelial differentiation G-protein coupled receptor 3, Sphingosine 1-phosphate receptor Edg-3, S1P receptor Edg-3, S1PR3, EDG3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6139a was selected from the N-term region of human EDG3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver|
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Provided below are standard protocols that you may find useful for product applications.
EDG3 is a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function.
Licht, T., et al., Blood 102(6):2099-2107 (2003).Himmel, H.M., et al., Mol. Pharmacol. 58(2):449-454 (2000).An, S., et al., J. Biol. Chem. 275(1):288-296 (2000).Ancellin, N., et al., J. Biol. Chem. 274(27):18997-19002 (1999).Lee, M.J., et al., Cell 99(3):301-312 (1999).
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