EDG3 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q99500 |
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Clone Names | 2092009 |
Gene ID | 1903 |
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Other Names | Sphingosine 1-phosphate receptor 3, S1P receptor 3, S1P3, Endothelial differentiation G-protein coupled receptor 3, Sphingosine 1-phosphate receptor Edg-3, S1P receptor Edg-3, S1PR3, EDG3 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6139a was selected from the N-term region of human EDG3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | S1PR3 (HGNC:3167) |
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Function | Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. |
Cellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Location | Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
EDG3 is a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function.
References
Licht, T., et al., Blood 102(6):2099-2107 (2003).Himmel, H.M., et al., Mol. Pharmacol. 58(2):449-454 (2000).An, S., et al., J. Biol. Chem. 275(1):288-296 (2000).Ancellin, N., et al., J. Biol. Chem. 274(27):18997-19002 (1999).Lee, M.J., et al., Cell 99(3):301-312 (1999).
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