EDG5 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O95136 |
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Other Accession | NP_004221 |
Clone Names | 2092010 |
Gene ID | 9294 |
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Other Names | Sphingosine 1-phosphate receptor 2, S1P receptor 2, S1P2, Endothelial differentiation G-protein coupled receptor 5, Sphingosine 1-phosphate receptor Edg-5, S1P receptor Edg-5, S1PR2, EDG5 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6141a was selected from the N-term region of human EDG5 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | S1PR2 |
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Synonyms | EDG5 |
Function | Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10617617). When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis (PubMed:10617617). Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). |
Cellular Location | Cell membrane; Multi-pass membrane protein. |
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Provided below are standard protocols that you may find useful for product applications.
Background
EDG5 is a member of the G protein-coupled receptors, as well as the EDG family of proteins. This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation.
References
An, S., et al., J. Biol. Chem. 275(1):288-296 (2000).Ancellin, N., et al., J. Biol. Chem. 274(27):18997-19002 (1999).MacLennan, A.J., et al., Mol. Cell. Neurosci. 5(3):201-209 (1994).Spiegel, S., Ann. N. Y. Acad. Sci. 905, 54-60 (2000).Takuwa, Y., Tanpakushitsu Kakusan Koso 47 (4 Suppl), 496-502 (2002).
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