|Other Names||Sphingosine 1-phosphate receptor 2, S1P receptor 2, S1P2, Endothelial differentiation G-protein coupled receptor 5, Sphingosine 1-phosphate receptor Edg-5, S1P receptor Edg-5, S1PR2, EDG5|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6141a was selected from the N-term region of human EDG5 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
EDG5 is a member of the G protein-coupled receptors, as well as the EDG family of proteins. This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation.
An, S., et al., J. Biol. Chem. 275(1):288-296 (2000).Ancellin, N., et al., J. Biol. Chem. 274(27):18997-19002 (1999).MacLennan, A.J., et al., Mol. Cell. Neurosci. 5(3):201-209 (1994).Spiegel, S., Ann. N. Y. Acad. Sci. 905, 54-60 (2000).Takuwa, Y., Tanpakushitsu Kakusan Koso 47 (4 Suppl), 496-502 (2002).
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