|Other Names||Sphingosine 1-phosphate receptor 4, S1P receptor 4, S1P4, Endothelial differentiation G-protein coupled receptor 6, Sphingosine 1-phosphate receptor Edg-6, S1P receptor Edg-6, S1PR4, EDG6|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6142a was selected from the N-term region of human EDG6 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung|
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Provided below are standard protocols that you may find useful for product applications.
EDG6 is a member of the G protein-coupled receptors, as well as the EDG family of proteins. It participates in endothelial differentiation, and may regulate lymphocyte cell signaling. It is a member of the lysophospholipid/lysosphingolipid receptor family.
Contos, J.J., et al., FEBS Lett. 531(1):99-102 (2002).Yamazaki, Y., et al., Biochem. Biophys. Res. Commun. 268(2):583-589 (2000).Graler, M.H., et al., Genomics 53(2):164-169 (1998).
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