|Other Names||Lysophosphatidic acid receptor 3, LPA receptor 3, LPA-3, Lysophosphatidic acid receptor Edg-7, LPAR3, EDG7, LPA3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6143a was selected from the C-term region of human EDG7 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
EDG7 is a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.
Fujita, T., et al., Cancer Lett. 192(2):161-169 (2003).Im, D.S., et al., Mol. Pharmacol. 57(4):753-759 (2000).Fitzgerald, L.R., et al., Biochem. Biophys. Res. Commun. 273(3):805-810 (2000).Bandoh, K., et al., J. Biol. Chem. 274(39):27776-27785 (1999).Hama, K., et al., FEBS Lett. 523 (1-3), 187-192 (2002).
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