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EDG8 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
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- BACKGROUND
| Primary Accession | Q9H228 |
|---|---|
| Other Accession | NP_110387 |
| Gene ID | 53637 |
|---|---|
| Other Names | Sphingosine 1-phosphate receptor 5, S1P receptor 5, S1P5, Endothelial differentiation G-protein-coupled receptor 8, Sphingosine 1-phosphate receptor Edg-8, S1P receptor Edg-8, S1PR5, EDG8 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6144a was selected from the N-term region of human EDG8 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | S1PR5 |
|---|---|
| Synonyms | EDG8 |
| Function | Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction, both intracellularly as a second messenger and extracellularly as a receptor ligand. EDG8, a receptor for S1P, is a member of the G protein-coupled receptor family, as well as the EDG family of proteins. Human, rat, and mouse EDG8 proteins possess 97% sequence identity and appear to signal via G(i/o)alpha proteins. Human EDG8 is expressed in spleen, corpus collosum, peripheral blood leukocytes, placenta, lung, aorta, and several fetal tissues. Its precise role remains to be determined.
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