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EDG8 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9H228
Other Accession NP_110387
Additional Information
Gene ID 53637
Other Names Sphingosine 1-phosphate receptor 5, S1P receptor 5, S1P5, Endothelial differentiation G-protein-coupled receptor 8, Sphingosine 1-phosphate receptor Edg-8, S1P receptor Edg-8, S1PR5, EDG8
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6144a was selected from the N-term region of human EDG8 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name S1PR5
Synonyms EDG8
Function Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes.
Research Areas
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The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction, both intracellularly as a second messenger and extracellularly as a receptor ligand. EDG8, a receptor for S1P, is a member of the G protein-coupled receptor family, as well as the EDG family of proteins. Human, rat, and mouse EDG8 proteins possess 97% sequence identity and appear to signal via G(i/o)alpha proteins. Human EDG8 is expressed in spleen, corpus collosum, peripheral blood leukocytes, placenta, lung, aorta, and several fetal tissues. Its precise role remains to be determined.

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$ 80.00
Cat# BP6144a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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