|Other Names||Protein jagged-1, Jagged1, hJ1, CD339, JAG1, JAGL1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6147a was selected from the C-term region of human JAG1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells|
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Provided below are standard protocols that you may find useful for product applications.
JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
LaVoie, M.J., et al., J. Biol. Chem. 278(36):34427-34437 (2003).Tohda, S., et al., Int. J. Oncol. 22(5):1073-1079 (2003).Lu, F., et al., Am. J. Hum. Genet. 72(4):1065-1070 (2003).Ascano, J.M., et al., J. Biol. Chem. 278(10):8771-8779 (2003).Masuya, M., et al., Int. J. Hematol. 75(3):269-276 (2002).
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