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Jagged1 (JAG1) Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P78504
Other Accession NP_000205
Clone Names 2081202
Additional Information
Gene ID 182
Other Names Protein jagged-1, Jagged1, hJ1, CD339, JAG1, JAGL1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6147a was selected from the C-term region of human JAG1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name JAG1
Synonyms JAGL1
Function Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells
Research Areas
Citations (0)

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JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.


LaVoie, M.J., et al., J. Biol. Chem. 278(36):34427-34437 (2003).Tohda, S., et al., Int. J. Oncol. 22(5):1073-1079 (2003).Lu, F., et al., Am. J. Hum. Genet. 72(4):1065-1070 (2003).Ascano, J.M., et al., J. Biol. Chem. 278(10):8771-8779 (2003).Masuya, M., et al., Int. J. Hematol. 75(3):269-276 (2002).

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$ 80.00
Cat# BP6147a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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