|Other Names||Protein jagged-2, Jagged2, hJ2, JAG2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6148a was selected from the C-term region of human JAG2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in heart, placenta and skeletal muscle and to a lesser extent in pancreas. Very low expression in brain, lung, liver and kidney|
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Provided below are standard protocols that you may find useful for product applications.
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. JAG2 is one of several ligands that activate Notch and related receptors.
Hayashi, T., et al., J. Androl. 22(6):999-1011 (2001).Lindner, V., et al., Am. J. Pathol. 159(3):875-883 (2001).Cereseto, A., et al., J. Cell. Physiol. 185(3):425-431 (2000).Tsai, S., et al., Blood 96(3):950-957 (2000).Deng, Y., et al., Genomics 63(1):133-138 (2000).
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