|Other Names||Leptin, Obese protein, Obesity factor, LEP, OB, OBS|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6150a was selected from the C-term region of human LEP . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.|
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Provided below are standard protocols that you may find useful for product applications.
Leptin (LEP) is an adipocyte-secreted protein that regulates body fat and endocrine functions. Leptin is similar to the mouse obesity protein encoded by the obese gene (ob). In mouse studies, mutations in this gene are linked to severe and morbid obesity.
Tank, J., et al., J. Clin. Endocrinol. Metab. 88(10):4955-4959 (2003).Silha, J.V., et al., Eur. J. Endocrinol. 149(4):331-335 (2003).Kazumi, T., et al., Metab. Clin. Exp. 52(9):1113-1116 (2003).Mullington, J.M., et al., J. Neuroendocrinol. 15(9):851-854 (2003).Catalano, S., et al., J. Biol. Chem. 278(31):28668-28676 (2003).
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