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Leptin Receptor (LEPR) Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P48357
Other Accession NP_002294
Clone Names 2090511
Additional Information
Gene ID 3953
Other Names Leptin receptor, LEP-R, HuB219, OB receptor, OB-R, CD295, LEPR, DB, OBR
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6151a was selected from the N-term region of human LEPR . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms DB, OBR
Function Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary Low level in lung and kidney. Isoform B is highly expressed in hypothalamus
Research Areas
Citations (0)

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Leptin, an adipocyte-specific hormone, regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure by acting through the leptin receptor (LEPR). LEPR is a single-transmembrane-domain receptor of the cytokine receptor family that is identical to the mouse diabetes (db) gene product. During weight loss, leptin levels decrease, whereas soluble LEPR levels and the receptor bound fraction of leptin increases. The presence of LEPR in the absorptive cells of the small intestine suggests that leptin may have a physiological role in the regulation of nutrient absorption.


Schroth, M., et al., J. Clin. Endocrinol. Metab. 88(11):5497-5501 (2003).Couturier, C., et al., J. Biol. Chem. 278(29):26604-26611 (2003).Gavrila, A., et al., J. Clin. Endocrinol. Metab. 88(6):2838-2843 (2003).Yannakoulia, M., et al., J. Clin. Endocrinol. Metab. 88(4):1730-1736 (2003).Kado, N., et al., Hum. Reprod. 18(4):715-720 (2003).

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$ 80.00
Cat# BP6151a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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