|Other Names||Melanoma-associated antigen 12, Cancer/testis antigen 112, CT112, MAGE-12 antigen, MAGE12F antigen, MAGEA12, MAGE12|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6162a was selected from the N-term region of human MAGEA12 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines.|
|Tissue Location||Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes|
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Provided below are standard protocols that you may find useful for product applications.
MAGEA12 is a member of the melanoma antigen gene (MAGE) family. The proteins of this family are tumor-specific antigens that can be recognized by autologous cytolytic T lymphocytes. This gene is expressed in various tumors and tumor cell lines from different tissue origins, but not detected in normal tissues, except testis. The function of this gene is unknown. This and other MAGE genes form a gene cluster at chromosome Xq28 region.
Mallon, A.M., et al., Genome Res. 10(6):758-775 (2000).Rogner, U.C., et al., Genomics 29(3):725-731 (1995).Ding, M., et al., Biochem. Biophys. Res. Commun. 202(1):549-555 (1994).De Smet, C., et al., Immunogenetics 39(2):121-129 (1994).De Plaen, E., et al., Immunogenetics 40(5):360-369 (1994).
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