|Other Names||Melanoma-associated antigen B1, Cancer/testis antigen 31, CT31, DSS-AHC critical interval MAGE superfamily 10, DAM10, MAGE-B1 antigen, MAGE-XP antigen, MAGEB1, MAGEL1, MAGEXP|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6171a was selected from the Center region of human MAGEB1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Expressed only in testis.|
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Provided below are standard protocols that you may find useful for product applications.
MAGEB1 is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region, and expressed in testis and in a significant fraction of tumors of various histological types. This gene and other MAGEB members are clustered on chromosome Xp22-p21.
Park, J.H., et al., Mol. Cells 13(2):288-295 (2002).Lurquin, C., et al., Genomics 46(3):397-408 (1997).Dabovic, B., et al., Mamm. Genome 6(9):571-580 (1995).Muscatelli, F., et al., Proc. Natl. Acad. Sci. U.S.A. 92(11):4987-4991 (1995).
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