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MAGEB2 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O15479
Other Accession NP_002355
Clone Names 2092209
Additional Information
Gene ID 4113
Other Names Melanoma-associated antigen B2, Cancer/testis antigen 32, CT32, DSS-AHC critical interval MAGE superfamily 6, DAM6, MAGE XP-2 antigen, MAGE-B2 antigen, MAGEB2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6172a was selected from the N-term region of human MAGEB2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAGEB2
Function May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.
Tissue Location Expressed in testis and placenta, and in a significant fraction of tumors of various histologic types
Research Areas
Citations (0)
citation

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Background

MAGEB2 is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21.

References

Park, J.H., et al., Mol. Cells 13(2):288-295 (2002).Lurquin, C., et al., Genomics 46(3):397-408 (1997).Dabovic, B., et al., Mamm. Genome 6(9):571-580 (1995).

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$ 277.78
Cat# BP6172a
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Availability: 2 weeks
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