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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   MAGEL2 Antibody (C-term) Blocking Peptide   

MAGEL2 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UJ55
Clone Names 2091605
Additional Information
Other Names MAGE-like protein 2, Necdin-like protein 1, Protein nM15, MAGEL2, NDNL1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6181a was selected from the C-term region of human MAGEL2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms NDNL1
Function Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys- 63'-linked polyubiquitin chains at 'Lys-220' of WASH1 together with TRIM27, leading to promote endosomal F-actin assembly (PubMed:23452853). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Significantly promotes the cytoplasmic accumulation of CLOCK (By similarity).
Cellular Location Early endosome. Cytoplasm {ECO:0000250|UniProtKB:Q9QZ04}. Nucleus {ECO:0000250|UniProtKB:Q9QZ04}. Note=Recruited to retromer- containing endosomes via interaction with VPS35. Colocalizes with CLOCK and ARNTL/BMLA1 in the cytoplasm, and with PER2 in the cytoplasm and nucleus (By similarity) {ECO:0000250|UniProtKB:Q9QZ04, ECO:0000269|PubMed:23452853}
Tissue Location Expressed in placenta, fetal and adult brain. Not detected in heart and small intestine, very low levels in fibroblasts. Not expressed in brain of a Prader-Willi patient
Research Areas
Citations (0)

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Melanoma-associated antigen (MAGE) are completely silent in normal tissues, with the exception of male germ cells, and, for some of them, placenta. These antigens ought to be strictly tumor specific, expressed in tumor cells of various histological types. Because of their specific expression on tumor cells, these antigens are of particular interest for antitumor immunotherapy. Genes of the MAGE family direct the expression of tumor antigens that are recognized on a human melanoma by autologous cytolytic T lymphocytes. Though the function of MAGE is unknown, may play a role in embryonal development and tumor transformation or aspects of tumor progression.


Lee, S., et al., Hum. Mol. Genet. 9(12):1813-1819 (2000).Boccaccio, I., et al., Hum. Mol. Genet. 8(13):2497-2505 (1999).

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$ 80.00
Cat# BP6181a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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