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MLLT6 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P55198
Other Accession NP_005928
Additional Information
Gene ID 4302
Other Names Protein AF-17, ALL1-fused gene from chromosome 17 protein, MLLT6, AF17
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6192a was selected from the C-term region of human MLLT6 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MLLT6
Synonyms AF17
Cellular Location Nucleus.
Research Areas
Citations (0)

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Band 11q23 chromosome locations are associated with approximately 10% of patients with acute lymphoblastic leukemia (ALL) and more than 5% of patients with acute myeloid leukemia (AML). 11q23 translocation associated leukemias typically jointly express lymphoid and myeloid markers and exhibit poor prognosis. The gene at 11q23 involved in the translocations is known by multiple names, including ALL1, HRX, MLL, and TRX1. One of the more infrequent translocations, t(11;17)(q23;q21), MLLT6, encodes a protein of 1,093 amino acids, containing a leucine-zipper dimerization motif 3-prime to the fusion point and a cysteine-rich domain at the end terminus that can be arranged in 3 zinc fingers. MMLT6 contains amino acid runs associated with domains involved in transcriptional repression or activation. It has been proposed that MLLT6 represses truncated ALL1 function or inhibits function of the normal protein in leukemic cells.


Prasad, R., et al., Proc. Natl. Acad. Sci. U.S.A. 91(17):8107-8111 (1994).

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$ 80.00
Cat# BP6192a
Availability: In Stock
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