|Other Names||Stromelysin-3, SL-3, ST3, 3424-, Matrix metalloproteinase-11, MMP-11, MMP11, STMY3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6195a was selected from the C-term region of human MMP11 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play an important role in the progression of epithelial malignancies.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Specifically expressed in stromal cells of breast carcinomas|
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Provided below are standard protocols that you may find useful for product applications.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP11 may play an important role in the progression of epithelial malignancies. It is specifically expressed in stromal cells of breast carcinomas.
Anglard, P., et al., J. Biol. Chem. 270(35):20337-20344 (1995).Basset, P., et al., Nature 348(6303):699-704 (1990).
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