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MMP12 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P39900
Other Accession NP_002417
Clone Names 2090307
Peptide ID 2090307
Additional Information
Gene ID 4321
Other Names Macrophage metalloelastase, MME, Macrophage elastase, ME, hME, Matrix metalloproteinase-12, MMP-12, MMP12, HME
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6196a was selected from the C-term region of human MMP12 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MMP12
Synonyms HME
Function May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Found in alveolar macrophages but not in peripheral blood monocytes
Research Areas
Citations (0)

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Background

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP12 may be involved in tissue injury and remodeling. This protein has significant elastolytic activity. MMP12 can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, wtih small hydrophobic residues (prefereably alanine) occupying P3. The protein is found in alveolar macrophages but not in peripheral blood monocytes. MMP12 can be induced by exposure to lypopolysaccharide, and is inhibited by dexamethasone.

References

Nar, H., et al., J. Mol. Biol. 312(4):743-751 (2001).Lang, R., et al., J. Mol. Biol. 312(4):731-742 (2001).Gronski, T.J. Jr., et al., J. Biol. Chem. 272(18):12189-12194 (1997).Shapiro, S.D., et al., J. Biol. Chem. 268(32):23824-23829 (1993).

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$ 80.00
Cat# BP6196a
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