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MMP8 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P22894
Other Accession NP_002415
Clone Names 2090303
Peptide ID 2090303
Additional Information
Gene ID 4317
Other Names Neutrophil collagenase, Matrix metalloproteinase-8, MMP-8, PMNL collagenase, PMNL-CL, MMP8, CLG1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6213a was selected from the Center region of human MMP8 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MMP8
Synonyms CLG1
Function Can degrade fibrillar type I, II, and III collagens.
Cellular Location Cytoplasmic granule. Secreted, extracellular space, extracellular matrix. Note=Stored in intracellular granules
Tissue Location Neutrophils.
Research Areas
Citations (0)

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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP8 is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.


Van den Steen, P.E., et al., Biochem. Biophys. Res. Commun. 310(3):889-896 (2003).Giambernardi, T.A., et al., Matrix Biol. 20(8):577-587 (2001).Nagase, H., et al., J. Biol. Chem. 274(31):21491-21494 (1999).Massova, I., et al., FASEB J. 12(12):1075-1095 (1998).Pendas, A.M., et al., Genomics 37(2):266-268 (1996).

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$ 80.00
Cat# BP6213a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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