|Other Names||Neutrophil collagenase, Matrix metalloproteinase-8, MMP-8, PMNL collagenase, PMNL-CL, MMP8, CLG1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6213a was selected from the Center region of human MMP8 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Can degrade fibrillar type I, II, and III collagens.|
|Cellular Location||Cytoplasmic granule. Secreted, extracellular space, extracellular matrix. Note=Stored in intracellular granules|
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Provided below are standard protocols that you may find useful for product applications.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP8 is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Van den Steen, P.E., et al., Biochem. Biophys. Res. Commun. 310(3):889-896 (2003).Giambernardi, T.A., et al., Matrix Biol. 20(8):577-587 (2001).Nagase, H., et al., J. Biol. Chem. 274(31):21491-21494 (1999).Massova, I., et al., FASEB J. 12(12):1075-1095 (1998).Pendas, A.M., et al., Genomics 37(2):266-268 (1996).
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