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NOTCH3 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UM47
Clone Names 2091807
Peptide ID 2091807
Additional Information
Gene ID 4854
Other Names Neurogenic locus notch homolog protein 3, Notch 3, Notch 3 extracellular truncation, Notch 3 intracellular domain, NOTCH3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6220a was selected from the C-term region of human NOTCH3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Ubiquitously expressed in fetal and adult tissues
Research Areas
Citations (0)

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NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).


Suwanwela, N., et al., J Med Assoc Thai 86(2):178-182 (2003).Ahearn, E.P., et al., Am. J. Med. Genet. 114(6):652-658 (2002).Bellavia, D., et al., Proc. Natl. Acad. Sci. U.S.A. 99(6):3788-3793 (2002).Ito, D., et al., J. Neurol. Neurosurg. Psychiatr. 72(3):382-384 (2002).Joutel, A., et al., Lancet 350(9090):1511-1515 (1997).

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$ 80.00
Cat# BP6220a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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