|Other Names||Pro-neuregulin-4, membrane-bound isoform, Pro-NRG4, Neuregulin-4, NRG-4, NRG4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6225b was selected from the center region of human NRG4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).|
|Cellular Location||Pro-neuregulin-4, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein. Note=Does not seem to be active.|
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Provided below are standard protocols that you may find useful for product applications.
The Pro-neuregulin-4, membrane-bound isoform contains 1 EGF-like domain and belongs to the neuregulin family. It is low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. However, it does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).
Memon, A.A., et al., Br. J. Cancer 91(12):2034-2041 (2004).
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