|Other Names||2'-5'-oligoadenylate synthase 2, (2-5')oligo(A) synthase 2, 2-5A synthase 2, p69 OAS / p71 OAS, p69OAS / p71OAS, OAS2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6227a was selected from the C-term region of human OAS2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions|
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Provided below are standard protocols that you may find useful for product applications.
OAS2 is an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance.
Hovnanian, A., et al., Genomics 52(3):267-277 (1998).Marie, I., et al., J. Biol. Chem. 267(14):9933-9939 (1992).Marie, I., et al., J. Biol. Chem. 265(30):18601-18607 (1990).Marie, I., et al., Biochem. Biophys. Res. Commun. 160(2):580-587 (1989).Hovanessian, A.G., et al., EMBO J. 6(5):1273-1280 (1987).
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