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PSEN2 Antibody (N-term) Blocking PeptideSynthetic peptide
| Country | United States
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| Catalog # | Size | Availability | Price | |
| BP6232a | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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PSEN2 Antibody (N-term) Blocking Peptide - Product info | |
| Primary Accession | P49810 |
| Clone Names | 2081610 |
| Calculated MW | 50140 Da |
PSEN2 Antibody (N-term) Blocking Peptide - Additional info | |
| Gene ID 5664 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP6232a was selected from the N-term region of human PSEN2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
PSEN2 Antibody (N-term) Blocking Peptide - Protein Information | |
| Name PSEN2 | |
| Synonyms AD4, PS2, PSNL2, STM2 | |
| Function Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins | |
| Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein | |
| Tissue Location Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney | |
PSEN2 Antibody (N-term) Blocking Peptide - Related products
AP6232a: Presenilin 2 (PSEN2) Antibody (N-term)
AP6304c: Presenilin 2/1 (PSEN2/PSEN1) Antibody (N-term)
AP6305a: Presenilin 2 (PSEN2) Antibody (C-term)
AP6305b: Presenilin 2 (PSEN2) Antibody (N-term)
RI14267: PSEN2 predesign siRNA
BP6232a: PSEN2 Antibody (N-term) Blocking Peptide
BP6304c: PSN2/1 Antibody (C-term) Blocking Peptide
BP6305a: PSN2 Antibody (C-term) Blocking Peptide
BP6305b: PSN2 Antibody (N-term) Blocking Peptide
AJ1651a: Presenilin-2 Antibody
PSEN2 Antibody (N-term) Blocking Peptide - Research Areas
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BACKGROUND
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that that they either directly regulate gamma-secretase activity or themselves are protease enzymes.
REFERENCES
Ezquerra, M., et al., Arch. Neurol. 60(8):1149-1151 (2003).Beher, D., et al., Biochemistry 42(27):8133-8142 (2003).Di Natale, M., et al., Neurosci. Lett. 343(3):210-212 (2003).Alves da Costa, C., et al., J. Biol. Chem. 278(14):12064-12069 (2003).Gu, Y., et al., J. Biol. Chem. 278(9):7374-7380 (2003).
