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SMYD5 (RAI15) Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6GMV2 |
|---|---|
| Other Accession | NP_006053 |
| Clone Names | 2092404 |
| Gene ID | 10322 |
|---|---|
| Other Names | SET and MYND domain-containing protein 5, 211-, Protein NN8-4AG, Retinoic acid-induced protein 15, SMYD5, RAI15 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6234a was selected from the C-term region of human RAI15 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SMYD5 |
|---|---|
| Synonyms | RAI15 |
| Function | Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 to form trimethylated histone H4 lysine 20 (H4K20me3) which represents a specific tag for epigenetic transcriptional repression (By similarity). In association with the NCoR corepressor complex, is involved in the repression of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the formation of H4K20me3 at the gene promoters (By similarity). Plays an important role in embryonic stem (ES) cell self- renewal and differentiation (By similarity). Promotes ES cell maintenance by silencing differentiation genes through deposition of H4K20me3 marks (By similarity). Maintains genome stability of ES cells during differentiation through regulation of heterochromatin formation and repression of endogenous repetitive DNA elements by depositing H4K20me3 marks (PubMed:28951459). |
Research Areas
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$ 277.78
Cat# BP6234a
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