|Other Names||Hsc70-interacting protein, Hip, Aging-associated protein 2, Progesterone receptor-associated p48 protein, Protein FAM10A1, Putative tumor suppressor ST13, Renal carcinoma antigen NY-REN-33, Suppression of tumorigenicity 13 protein, ST13, AAG2, FAM10A1, HIP, SNC6|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6247a was selected from the N-term region of human ST13 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||AAG2, FAM10A1, HIP, SNC6|
|Function||One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
ST13 is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this protein is reported to be downregulated in colorectal carcinoma tissue suggesting that is a candidate tumor suppressor.
Rajapandi, T., et al., J. Biol. Chem. 275(29):22597-22604 (2000).Morishima, Y., et al., J. Biol. Chem. 275(10):6894-6900 (2000).Chen, S., et al., J. Biol. Chem. 273(52):35194-35200 (1998).Johnson, B.D., et al., J. Biol. Chem. 273(6):3679-3686 (1998).Cao, J., et al., J. Cancer Res. Clin. Oncol. 123(8):447-451 (1997).
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