|Other Names||CD82 antigen, C33 antigen, IA4, Inducible membrane protein R2, Metastasis suppressor Kangai-1, Suppressor of tumorigenicity 6 protein, Tetraspanin-27, Tspan-27, CD82, CD82, KAI1, SAR2, ST6, TSPAN27|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6250a was selected from the C-term region of human ST6 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KAI1, SAR2, ST6, TSPAN27|
|Function||Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Lymphoid specific.|
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Provided below are standard protocols that you may find useful for product applications.
The ST6 metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients.
Zhang, X.A., et al., J. Biol. Chem. 278(29):27319-27328 (2003).Zhang, X.A., et al., Cancer Res. 63(10):2665-2674 (2003).Yang, J., et al., Ai Zheng 22(5):533-536 (2003).Sauer, G., et al., Oncol. Rep. 10(2):405-410 (2003).Ito, Y., et al., Pathol Res Pract 199(2):79-83 (2003).
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