|Other Names||Thrombopoietin, C-mpl ligand, ML, Megakaryocyte colony-stimulating factor, Megakaryocyte growth and development factor, MGDF, Myeloproliferative leukemia virus oncogene ligand, THPO, MGDF|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6254a was selected from the N-term region of human TPO . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.|
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Provided below are standard protocols that you may find useful for product applications.
Megakaryocytopoiesis is the cellular development process that leads to platelet production. TTPO is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene.
Hirayama, Y., et al., Am. J. Hematol. 73(4):285-289 (2003).Webb, K.E., et al., Exp. Hematol. 31(6):488-494 (2003).Tsao, P.N., et al., Biol. Neonate 82(4):217-221 (2002).Hsu, H.C., et al., Oncology 63(1):64-69 (2002).Holmes, M.L., et al., J. Biol. Chem. 277(50):48333-48341 (2002).
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