|Other Names||Nectin-1, Herpes virus entry mediator C, Herpesvirus entry mediator C, HveC, Herpesvirus Ig-like receptor, HIgR, Poliovirus receptor-related protein 1, CD111, PVRL1, HVEC, PRR1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6259a was selected from the C-term region of human PVRL1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Functions as an entry receptor for herpes simplex virus and pseudorabies virus. Has some neurite outgrowth-promoting activity.|
|Cellular Location||Isoform Alpha: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, presynaptic cell membrane Isoform Gamma: Secreted.|
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Provided below are standard protocols that you may find useful for product applications.
Bender, F.C., et al., J. Virol. 77(17):9542-9552 (2003).Yoon, M., et al., J. Virol. 76(14):7203-7208 (2002).Lopez, M., et al., J. Virol. 75(12):5684-5691 (2001).Suzuki, K., et al., Nat. Genet. 25(4):427-430 (2000).Cocchi, F., et al., Proc. Natl. Acad. Sci. U.S.A. 95(26):15700-15705 (1998).
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