|Other Names||Poliovirus receptor, Nectin-like protein 5, NECL-5, CD155, PVR, PVS|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6260a was selected from the C-term region of human PVR . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.|
|Cellular Location||Isoform Alpha: Cell membrane; Single-pass type I membrane protein Isoform Beta: Secreted.|
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The poliovirus receptor (PVR) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. PVR is involved in intercellular adhesion and its cytoplasmic domain may target endocytic vesicles to the microtubular network. The extracellular domain of PVR mediates cell attachment to the extracellular matrix molecule vitronectin, while its cytoplasmic domain interacts with the dynein light chain Tctex-1. PVR is a primate-restricted protein expressed during development in mesenchymal tissues and ventrally derived structures within the CNS. Its exact biological function remains to be determined; it is reported that PVR is aberrantly expressed in tumors of neuroectodermal origin.
Zibert, A., et al., J. Virol. 66(12):7368-7373 (1992).Koike, S., et al., Proc. Natl. Acad. Sci. U.S.A. 88(10):4104-4108 (1991).Koike, S., et al., EMBO J. 9(10):3217-3224 (1990).Mendelsohn, C.L., et al., Cell 56(5):855-865 (1989).
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