|Other Names||Growth factor receptor-bound protein 2, Adapter protein GRB2, Protein Ash, SH2/SH3 adapter GRB2, GRB2, ASH|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6283a was selected from the Y209 region of human GRB2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.|
|Cellular Location||Nucleus. Cytoplasm. Endosome. Golgi apparatus|
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Provided below are standard protocols that you may find useful for product applications.
GRB2 binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway.
Kondo,A., J. Biol. Chem. 283 (3), 1428-1436 (2008)Morimatsu,M., Proc. Natl. Acad. Sci. U.S.A. 104 (46), 18013-18018 (2007)Martinez,N., Cell. Signal. 19 (11), 2277-2285 (2007)
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