GRB2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P62993 |
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Clone Names | 80220151 |
Gene ID | 2885 |
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Other Names | Growth factor receptor-bound protein 2, Adapter protein GRB2, Protein Ash, SH2/SH3 adapter GRB2, GRB2, ASH |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6283b was selected from the N-term region of human GRB2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GRB2 |
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Synonyms | ASH |
Function | Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. |
Cellular Location | Nucleus. Cytoplasm. Endosome Golgi apparatus {ECO:0000250|UniProtKB:Q60631} |
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Provided below are standard protocols that you may find useful for product applications.
Background
GRB2 binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences.
References
Kondo,A., J. Biol. Chem. 283 (3), 1428-1436 (2008)Morimatsu,M., Proc. Natl. Acad. Sci. U.S.A. 104 (46), 18013-18018 (2007)Martinez,N., Cell. Signal. 19 (11), 2277-2285 (2007)
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