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PEN2 Antibody (N-term M1) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NZ42
Clone Names 3120808
Additional Information
Gene ID 55851
Other Names Gamma-secretase subunit PEN-2, Presenilin enhancer protein 2, PSENEN, PEN2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6301a was selected from the N-term region of human PEN2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PSENEN
Synonyms PEN2
Function Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein Note=Predominantly located in the endoplasmic reticulum and in the cis- Golgi.
Tissue Location Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.
Research Areas
Citations (0)
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Background

Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. PEN2 is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.

References

Marlow, L., et al., Biochem. Biophys. Res. Commun. 305(3):502-509 (2003).Crystal, A.S., et al., J. Biol. Chem. 278(22):20117-20123 (2003).Takasugi, N., et al., Nature 422(6930):438-441 (2003).Steiner, H., et al., J. Biol. Chem. 277(42):39062-39065 (2002).Francis, R., et al., Dev. Cell 3(1):85-97 (2002).

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$ 277.78
Cat# BP6301a
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