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PEN2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9NZ42
Clone Names 4092451
Additional Information
Gene ID 55851
Other Names Gamma-secretase subunit PEN-2, Presenilin enhancer protein 2, PSENEN, PEN2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6301d was selected from the N-term region of human PEN2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms PEN2
Function Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi- pass membrane protein. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi
Tissue Location Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.
Research Areas
Citations (0)

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Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. PEN2 is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.


Marlow, L., et al., Biochem. Biophys. Res. Commun. 305(3):502-509 (2003).Crystal, A.S., et al., J. Biol. Chem. 278(22):20117-20123 (2003).Takasugi, N., et al., Nature 422(6930):438-441 (2003).Steiner, H., et al., J. Biol. Chem. 277(42):39062-39065 (2002).Francis, R., et al., Dev. Cell 3(1):85-97 (2002).

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$ 80.00
Cat# BP6301d
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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