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Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q92542 |
|---|---|
| Other Accession | NICA_HUMAN |
| Clone Names | 3120815 |
| Peptide ID | 3120815 |
| Gene ID | 23385 |
|---|---|
| Other Names | Nicastrin, NCSTN, KIAA0253 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6303b was selected from the Center region of human NICA . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NCSTN |
|---|---|
| Synonyms | KIAA0253 |
| Function | Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. |
| Cellular Location | Membrane; Single-pass type I membrane protein. Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV |
| Tissue Location | Widely expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Nicastrin is a type 1 transmembrane glycoprotein that interacts with both presenilin-1 (PSEN1) and presenilin-2 (PSEN2) and has a central role in presenilin-mediated processing of beta-amyloid precursor protein (beta-APP) and some aspects of NOTCH/glp-1 signaling in vivo.
References
Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003).Li, J., et al., J. Biol. Chem. 278(35):33445-33449 (2003).Marlow, L., et al., Biochem. Biophys. Res. Commun. 305(3):502-509 (2003).Murphy, M.P., et al., FASEB J. 17(9):1138-1140 (2003).Shirotani, K., et al., J. Biol. Chem. 278(19):16474-16477 (2003).
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