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Nicastrin (NICA) Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q92542 |
|---|---|
| Other Accession | NICA_HUMAN |
| Clone Names | 3120815 |
| Gene ID | 23385 |
|---|---|
| Other Names | Nicastrin, NCSTN, KIAA0253 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6303b was selected from the Center region of human NICA . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NCSTN |
|---|---|
| Synonyms | KIAA0253 |
| Function | Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. |
| Cellular Location | Membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV |
| Tissue Location | Detected in brain (at protein level) (PubMed:10993067). Widely expressed (PubMed:11396676) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Nicastrin is a type 1 transmembrane glycoprotein that interacts with both presenilin-1 (PSEN1) and presenilin-2 (PSEN2) and has a central role in presenilin-mediated processing of beta-amyloid precursor protein (beta-APP) and some aspects of NOTCH/glp-1 signaling in vivo.
References
Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003).Li, J., et al., J. Biol. Chem. 278(35):33445-33449 (2003).Marlow, L., et al., Biochem. Biophys. Res. Commun. 305(3):502-509 (2003).Murphy, M.P., et al., FASEB J. 17(9):1138-1140 (2003).Shirotani, K., et al., J. Biol. Chem. 278(19):16474-16477 (2003).
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