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Nicastrin (NICA) Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q92542
Other Accession NICA_HUMAN
Clone Names 3120816
Peptide ID 3120816
Additional Information
Gene ID 23385
Other Names Nicastrin, NCSTN, KIAA0253
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6303c was selected from the C-term region of human NICA . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA0253
Function Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
Cellular Location Membrane; Single-pass type I membrane protein. Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Nicastrin is a type 1 transmembrane glycoprotein that interacts with both presenilin-1 (PSEN1) and presenilin-2 (PSEN2) and has a central role in presenilin-mediated processing of beta-amyloid precursor protein (beta-APP) and some aspects of NOTCH/glp-1 signaling in vivo.


Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003).Li, J., et al., J. Biol. Chem. 278(35):33445-33449 (2003).Marlow, L., et al., Biochem. Biophys. Res. Commun. 305(3):502-509 (2003).Murphy, M.P., et al., FASEB J. 17(9):1138-1140 (2003).Shirotani, K., et al., J. Biol. Chem. 278(19):16474-16477 (2003).

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$ 80.00
Cat# BP6303c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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